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(E)-GABAB receptor antagonist 1

CAS No. 1611483-29-4

(E)-GABAB receptor antagonist 1 ( —— )

Catalog No. M26186 CAS No. 1611483-29-4

(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 264 Get Quote
5MG 402 Get Quote
10MG 593 Get Quote
25MG 888 Get Quote
50MG 1242 Get Quote
100MG 1701 Get Quote
500MG 3411 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    (E)-GABAB receptor antagonist 1
  • Note
    Research use only, not for human use.
  • Brief Description
    (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.
  • Description
    (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. GABAB receptor antagonist 1 (compound 14) is a selective and negative allosteric modulator of GABAB (γ-Aminobutyric acid) receptors.(In Vitro):(E)-GABAB receptor antagonist 1 reduces the maximum effect of IP3 in HEK293 cells overexpressing GABAB receptor and Gqi9 protein induced by agonist GABA, but does not alter EC50.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Adenine phosphoribosyltransferase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1611483-29-4
  • Formula Weight
    304.4
  • Molecular Formula
    C18H24O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)C(/C=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1)=O.[(E)]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Edamura K, et al. No self-injurious behavior was found in HPRT-deficient mice treated with 9-ethyladenine. Pharmacol Biochem Behav. 1998 Oct;61(2):175-9.
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